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diclofenac) • Good anti-inflammatory and analgesic effect Side effects Common • Dyspepsia • Abdominal pain • Nausea • Diarrhea Serious • Peptic ulcer & GI bleeding • Acute kidney injury • Elevated liver enzymes • Fluid retention, edema • Hypertension Contraindications • Active peptic ulcer disease • Severe renal or hepatic impairment • NSAID hypersensitivity / aspirin-induced asthma • Third trimester of pregnancy Drug interactions • Anticoagulants → ↑ bleeding risk • ACE inhibitors / diuretics → ↑ renal toxicity • Other NSAIDs → ↑ GI toxicity • Aceclofenac is a diclofenac derivative • Less gastric irritation but NOT GI-safe • Avoid in CKD and late pregnancy • No disease-modifying effect in arthritis (symptomatic relief only) To view or add a comment, sign in NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) NSAIDs are medications used to relieve pain, reduce inflammation, and lower fever by inhibiting prostaglandin synthesis

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