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A chart assembled that way is arithmetic, not evidence, and it hides the specific unknown that matters: both molecules require slow escalation because their gastrointestinal effects are dose-related, and no monitored study has characterised where the combined ceiling sits
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Diameter:6.3mm
For people with T2D, a phase 2 trial with mazdutide (doses 3, 4.5 and 6 mg) has shown reduction in HbA1c (up to −1.7%) and up to 7.1% WL at 20 weeks (Table 3), while early phase trials for MASH are in progress [72]
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